A recent study from the USA suggests that popular acid reflux medications like Omeprazole may be linked to an increased risk of migraines. Researchers found that individuals using acid-reducing drugs, including proton pump inhibitors (PPIs) like omeprazole, histamine H2-receptor antagonists, and antacid supplements, were more likely to experience severe headaches compared to those not taking these medications.
Acid reflux, a condition where stomach acid flows back into the esophagus, can cause discomfort such as heartburn and ulcers. Long-term acid reflux issues may lead to gastroesophageal reflux disease (GERD) and potentially increase the risk of esophageal cancer. Professor Margaret Slavin from the University of Maryland emphasized the need for further investigation into the potential connection between acid reflux drugs and migraines.
The study involved over 11,800 participants who reported their use of prescribed acid-reducing medications and their history of migraines or severe headaches. Results showed that individuals taking PPIs had a 25% incidence of migraines or severe headaches, higher than the 19% rate among non-users. Similarly, those using H2 blockers and antacid supplements also showed increased rates of severe headaches compared to non-users.
After adjusting for various factors like age, sex, caffeine, and alcohol consumption, the researchers discovered that individuals on PPIs were 70% more likely to experience migraines, while those on H2 blockers and antacid supplements had 40% and 30% higher chances, respectively. The findings were published in the journal Neurology Clinical Practice.
While acknowledging the necessity of acid-reducing medications for managing reflux and related conditions, Professor Slavin advised individuals with migraines or severe headaches who are on these drugs to consult their doctors regarding their continued use. Although previous research hinted at a possible link between gastrointestinal issues and migraines, the study’s results suggest a more direct association between acid reflux medications and migraines.